Kennisbank
Wetenschappelijke onderbouwing
LHM Diagnostiek vindt het delen van informatie en kennis erg belangrijk. Daarom organiseert LHM Diagnostiek samen partners regelmatig informatieve en interactieve webinars. Wilt u weten wanneer de volgende webinar gepland staat? Kijk dan op onze pagina webinars.
Op deze pagina kunt u alle gepubliceerde wetenschappelijke artikelen vinden die onze testen onderbouwen. Zo vindt u literatuur voor het ImuPro concept, de MetaCheck analyse, de NeuroSpot, de unieke darmflora test, de MELISA test en de toxische stoffen.
Voor inhoudelijke vragen of informatie over de studies kunt u Contact met ons opnemen.
ImuPro
Immunologie en inflammatie
- Aalberse RC et al. (2009) Immunoglobulin G4: an odd antibody. Clin. Exp. Allergy, 39 469-477:
- Castro-Dopico T. et al. (2019). IgG and Fcγ Receptors in Intestinal Immunity and Inflammation. Front. Immunol., 10
- Eisenmann A. et al. (2009). Gliadin IgG antibodies and circulating immune complexes Scand. J. Gastroenterol., 44: 168–71.
- Hoh RA. et al. (2018) Gut Mucosal Antibody Responses and Implications for Food Allergy. Front. Immunol., 9: 2221.
- Jönsson F. et al. (2011) Mouse and human neutrophils induce anaphylaxis. J. Clin. Invest., 121: 1484–96.
- Kim EH. et al. (2015) Immunological basis of food allergy (IgE-mediated, non-IgE-mediated, and tolerance). Chem. Immunol. Allergy, 101: 8–17
- Ohsaki A et al. (2018) Maternal IgG Immune Complexes Induce Food Allergen–Specific Tolerance in Offspring. 142.
- Simeonova D. et al. (2018) Recognizing the Leaky Gut as a Trans-diagnostic Target for Neuro- immune Disorders Using Clinical Chemistry and Molecular Immunology Assays. 1641–1655
- Vidarsson G. et al. (2014) IgG subclasses and allotypes: from structure to effector functions. Front. Immunol., 5: 520
Prikkelbare Darm Syndroom & Ziekte van Crohn
- Bentz S et al. (2010) Clinical relevance of IgG antibodies against food antigens in Crohn’s disease: A double-blind crossover diet intervention study. Digestion, 81: 252–264
- Cai C. et al. (2014) Serological investigation of food specific immunoglobulin G antibodies in patients with inflammatory bowel diseases. Boone DL. (ed). PLoS One, 9: e112154
- Jian L. et al. (2018) Food exclusion based on IgG antibodies alleviates symptoms in ulcerative colitis: A Prospective Study. Inflamm. Bowel Dis., 24: 1918–1925.
- Kawaguchi T et al. (2015) Food antigen-induced immune responses in Crohn’s disease patients and experimental colitis mice. J Gastroenterol, 50: 394–406.
- Uzunismail H. et al, (2012) The effects of provocation by foods with raised IgG antibodies and additives on the course of Crohn’s disease: A pilot study. Turkish J. Gastroenterol., 23: 19–27.
- Wang G. et al. (2018), The utility of food antigen test in the diagnosis of Crohn’s disease and remission maintenance after exclusive enteral nutrition. Clin. Res. Hepatol. Gastroenterol., 42: 145–152.
- Ostrowska L et al. (2021) Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS-Results from an Open Label Study. J Clin Med. 10(19):4317. doi: 10.3390/jcm10194317. PMID: 34640335; PMCID: PMC8509634.
- Atkinson W. et al. (2004) Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut, 53: 1459–1464.
- Aydinlar EI. et al. (2013) IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache, 53: 514–525.
- Drisko J. et al. (2006) Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics. J. Am. Coll. Nutr., 25: 514–522
- Guo Hong et al. (2012) The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel syndrome with diarrhoea. J. Int. Med. Res., 40: 204–10.
- Mansueto P. et. al. (2015) Advances in Irritable Bowel Syndrome Food allergy in irritable bowel syndrome : the case of non-celiac wheat sensitivity. World J. Gastroenterol., 21: 7089–7109
Hoofdpijn & Migraine
- Zhao Z. et al. (2021) Association of Migraine with Its Comorbidities and Food Specific Immunoglobulin G Antibodies and Inflammatory Cytokines: Cross-Sectional Clinical Research. J Pain Res. 2021 Aug 5;14:2359-2368.
- Alpay K. et. al. (2010) , Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial. Cephalalgia, 30: 829–837
- Arroyave Hernández C. et al. (2007)Food allergy mediated by IgG antibodies associated with migraine in adults. Rev. Alerg. Mex., 54: 162–168.
- Aydinlar EI. et al. (2013) IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache, 53: 514–525.
- Mitchell N. et al. (2011) Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Nutr. J., 10: 85
- Lewis JE. et al. (2013) A pilot study eliminating immunologically-reactive foods from the diet and its effect on symptomatology and quality of life in persons with chronic migraines and headaches. Open J. Intern. Med., 03: 8–14.
Auto-immuunziektes
- Hvatum M et al. (2006), The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis. Gut, 55: 1240–1247
- Kaličanin D. et al. (2019) Evaluation of correlations between food-specific antibodies and clinical aspects of Hashimoto’s thyroiditis. J. Am. Coll. Nutr., 38; 259-266:
- Vojdani A et al. (2013) Cross-reaction between gliadin and different food and tissue antigens. Food Nutr. Sci., 04: 20–32.
Obesitas
- Wilders-Truschnig M. et al. (2008) IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles. Exp. Clin. Endocrinol. Diabetes, 116: 241–5
- Hotamisligil GS. et al. (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest., 95: 2409–15
- Kvehaugen AS. et al. (2017) Anti-Saccharomyces cerevisiae antibodies (ASCA) are associated with body fat mass and systemic inflammation, but not with dietary yeast consumption: A crosssectional study. BMC Obes., 4: 2–9
- Neuendorf R. et al. (2018) Impact of food immunoglobulin G-based elimination diet on subsequent food immunoglobulin G and quality of life in overweight/obese adults. J. Altern. Complement. Med., acm.2018.0310.
- Salamati S. et al. (2015) Baker’s yeast (Saccharomyces cerevisiae) antigen in obese and normal weight subjects. Clin. Obes., 5: 42–7.
Huidklachten
- Hon KL. et al. (2013) Circulating immunoglobulins, leucocytes and complements in childhood-onset atopic eczema. Indian J. Pediatr., 80: 128–13
- Liu Y. et al. (2018) Correlation between childhood eczema and specific IgG antibody level. J. Biol. Regul. Homeost. Agents, 32: 341–344.
- Onmus MY. et al. (2016) The Effect of Elimination Diet on Weight and Metabolic Parameters of Overweight or Obese Patients Who HaveFood Intolerance. Journal of Food and Nutrition Research (4;1-5)
MetaCheck
- Geibel. R.C. et al. (2017). Analysis of the distribution of metabolic types (Meta-types) in the European population and their association with demographic data. Int. Journal of Current Research. 9;11;60257-60262.
- Smith,C.E. et al. (2012) Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity. Int. J. Obes. (Lond) 36, 130-136.
- Julve,J. et al (2010) Human apolipoprotein A-II determines plasma triglycerides by regulating lipoprotein lipase activity and high-density lipoprotein proteome. Arterioscler. Thromb. Vasc. Biol. 30, 232-238.
- Levy,E. et al. (2001) The polymorphism at codon 54 of the FABP2 gene increases fat absorption in human intestinal explants. J. Biol. Chem. 276, 39679-39684.
- Albala,C. et al. (2004) Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women. Obes. Res. 12, 340-345.
- Marin,C. et al. (2005) The Ala54Thr polymorphism of the fatty acid-binding protein 2 gene is associated with a change in insulin sensitivity after a change in the type of dietary fat. Am. J. Clin. Nutr. 82, 196-200.
- Weiss,E.P. et al. (2007) FABP2 Ala54Thr genotype is associated with glucoregulatory function and lipid oxidation after a high-fat meal in sedentary nondiabetic men and women. Am. J. Clin. Nutr. 85, 102-108.
- De Luis,D.A. et al. (2006) Influence of ALA54THR polymorphism of fatty acid binding protein 2 on lifestyle modification response in obese subjects. Ann. Nutr. Metab 50, 354-360.
- Mitchell,J.A. et al. (2010) FTO genotype and the weight loss benefits of moderate intensityexercise. Obesity. (Silver. Spring) 18, 641-643.
- Meirhaeghe,A. et al. (2001) The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity. J. Clin. Endocrinol. Metab 86, 5881-5887.
- Oizumi,T. et al. (2001) Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample. Diabetes Care 24, 1579-1583.
- Strazzullo,P. et al. (2001) Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study. J. Hypertens. 19, 399-406.
- Shiwaku,K. et al. (2003) Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Int. J. Obes. Relat Metab Disord. 27, 1028-1036.
- Franks,P.W. et al. (2007) The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia 50, 2451-2460.
- Corella,D. et al. (2011) Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction. Int. J. Obes. (Lond) 35, 666-675.
- Rankinen,T. et al. (2010) FTO genotype is associated with exercise training-induced changes in body composition. Obesity. (Silver. Spring) 18, 322-326 (2010).
- Santiago,C. et al.(2011) Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance. Br. J. Sports Med. 45, 147-149.
- Galbete,C. et al. (2013) Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project. Genes Nutr. 8, 61-67.
NeuroSpot
- Marc DT et al. (2010) Ailts JW, Campeau DC, Bull MJ, Olson KL. Neurotransmitters excreted in the urine as biomarkers of nervous system activity: validity and clinical applicability. Neurosci Biobehav Rev. 2011 Jan;35(3):635-44. doi: 10.1016/j.neubiorev.2010.07.007.
- Mikawa Y. et al. (2013) Low serum concentrations of vitamin B6 and iron are related to panic attack and hyperventilation attack. Acta Med Okayama. 67(2):99-104. doi: 10.18926/AMO/49668. PMID: 23603926.
- Homan P. et al. (2015) Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression. Transl Psychiatry. 2015 Mar 17;5(3):e532. doi: 10.1038/tp.2015.25. PMID: 25781231; PMCID: PMC4354355.
- Sumi-Ichinose C. et al. (2001) Catecholamines and Serotonin Are Differently Regulated by Tetrahydrobiopterin: A studie from 6 pyrovoyltetrahydropterin synthase knock-out mice. Journal of Biological Chemistry; 276, 44.
- Jenkins TA. et al. (2016) Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. 8(1):56. doi: 10.3390/nu8010056 PMID: 26805875; PMCID: PMC4728667.
- Moffett JR. et al. (2003) Tryptophan and the immune response. Immunol Cell Biol. Aug;81(4):247-65. doi: 10.1046/j.1440-1711.2003.t01-1-01177.x. PMID: 12848846.
- Karu N. et al. (2016) Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study. BMC Nephrol. 17(1):171. doi: 10.1186/s12882-016-0387-3. PMID: 27832762; PMCID: PMC5103367.
Darmflora
- Wilson AS. et al. (2020) Diet and the Human Gut Microbiome: An International Review. Dig Dis Sci. 65(3):723-740. doi: 10.1007/s10620-020-06112-w. PMID: 32060812; PMCID: PMC7117800.
- Thursby E, Juge N. (2017) Introduction to the human gut microbiota. Biochem J. 16;474(11):1823-1836. doi: 10.1042/BCJ20160510. PMID: 28512250; PMCID: PMC5433529.
- Human Microbiome Project Consortium (2012) Structure, function and diversity of the healthy human microbiome. Nature. 13;486(7402):207-14. doi: 10.1038/nature11234. PMID: 22699609; PMCID: PMC3564958.
- Harmsen HJ. et al. (2002) Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Appl Environ Microbiol. 68(6):2982-90. doi: 10.1128/AEM.68.6.2982-2990.2002. PMID: 12039758; PMCID: PMC123985.
- Blaut M. et al. (2002), Molecular biological methods for studying the gut microbiota: the EU human gut flora project. Br J Nutr. 87 Suppl 2:S203-11. doi: 10.1079/BJNBJN/2002539. PMID: 12088520.
Toxische stoffen
- De Santis B et al. (2019) Role of mycotoxins in the pathobiology of autism: A first evidence. Nutr Neurosci;22(2):132-144. doi: 10.1080/1028415X.2017.1357793. Epub 2017 Aug 10. PMID: 28795659.
- Richard JL. (2007) Some major mycotoxins and their mycotoxicoses–an overview. Int J Food Microbiol. 20;119(1-2):3-10. doi: 10.1016/j.ijfoodmicro.2007.07.019. Epub 2007 Jul 31. PMID: 17719115.
- Guilford FT. et al. (2014) Deficient glutathione in the pathophysiology of mycotoxin-related illness. Toxins (Basel). 10;6(2):608-23. doi: 10.3390/toxins6020608. PMID: 24517907; PMCID: PMC3942754.
- Jiang Y et al. Aflatoxin-related immune dysfunction in health and in human immunodeficiency virus disease. Clin Dev Immunol. doi: 10.1155/2008/790309. PMID: 18695741; PMCID: PMC2496958.
- Park SH. et al. (2015) Effects of Mycotoxins on mucosal microbial infection and related pathogenesis. Toxins (Basel). 30;7(11):4484-502. doi: 10.3390/toxins7114484. PMID: 26529017; PMCID: PMC4663516.
- Silva MJ et al. (2003) Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Journal of chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 789(2):393-404. DOI: 10.1016/s1570-0232(03)00164-8. PMID: 12742130.
- Ormond G. et al. (2009) Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias: case-control study. Environ Health Perspect. 117(2):303-7. doi: 10.1289/ehp.11933. Epub 2008 Nov 20. PMID: 19270804; PMCID: PMC2649236.
- Eskenazi B. et al. (2004) Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect. 112(10):1116-24. doi: 10.1289/ehp.6789. PMID: 15238287; PMCID: PMC1247387.
- Brown TP. et al. (2006) Pesticides and Parkinson’s disease–is there a link? Environ Health Perspect. 114(2):156-64. doi: 10.1289/ehp.8095. PMID: 16451848; PMCID: PMC1367825.
- Perera FP et al. (2014) Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One. Nov 5;9(11):e111670. doi: 10.1371/journal.pone.0111670. PMID: 25372862; PMCID: PMC4221082.
- Bradberry SM. et al. (2004) Glyphosate poisoning. Toxicol Rev. 2004;23(3):159-67. doi: 10.2165/00139709-200423030-00003. PMID: 15862083.
- Mesnage R et al. (2014) Major pesticides are more toxic to human cells than their declared active principles. Biomed Res Int. 2014;2014:179691. doi: 10.1155/2014/179691. Epub PMID: 24719846; PMCID: PMC3955666.